Sildenafil is a generic medical compound that was synthesized by an elite group of scientists associated with the pharmaceutical company—Pfizer in the mid-1990s. Scientists developed the formulation of this medical compound with the vision to treat hypertension and angina. But, during the initial studies, the medicine showed a very mild effect on angina. Such failure in the experiments caused a big disappointment to the scientists. However, the team persevered with subsequent trials. Soon, in subsequent trials, Sildenafil started showing a positive effect on the condition of erectile dysfunction in men. This was a surprise as the doctors didn’t intend to treat male impotence with this medical compound. Such discovery led the company to patent the drug in 1996. And, about a couple of years later in 1998, Sildenafil Citrate was approved by the FDA for the treatment of erectile dysfunction.
Sildenafil became the first oral treatment that received approval from the regulatory board for the treatment of erectile dysfunction. Soon, the patent-holding company starting marketing the generic sildenafil pills for retail sale. As per the records, the sales figures for this particular pharmaceutical drug touched almost USD 2 billion mark.
How Does Sildenafil Citrate Work On Erectile Dysfunction?
Sildenafil Citrate, when kicks in the system and reduces the excess calcium deposit around the smooth muscles of the penis. The medical compound enables the brain to release more dopamine when the user gets some sexual stimulation. Also, on dissolving fully into the bloodstream, the chemical agents present in the drug target the blood vessels of the entire body, especially the penile region. Consequently, it opens up the blocked regions of the vessels to promote the flow of oxygenated blood to the organ. On receiving the sufficient amount of blood in the reproductive system, along with the release of the optimum level of dopamine, the user regains virility in the reproductive organ and achieves a healthy erection. The whole chemical process takes about 20 – 30 minutes to work in the human body.
The optimum Dose Of Sildenafil To Achieve A Perfect Erection
A human body usually can’t withstand the sudden chemical change in the body. That’s why doctors recommend an ED patient to start off with a mild dose of 50 mg sildenafil. It allows the body to cope up with the changing balance of the endogenous chemicals and react positively over the period of time. On getting used to the initial doses of 50 mg of sildenafil, ED patients are recommended to gradually increase the dose up to 100 mg at a time. This increment in the quantity of the medical compound ensures continuous improvement in the quality of the erection.
Common Brands Which Use Sildenafil As Active Ingredient To Formulate ED Medications:
- Kamagra Tablets/Kamagra Jelly
- Eriacta Tablets
- Silagra Tablets
Though there are other ED medications available which claim to contain sildenafil citrate as the prime ingredient, sexologists recommend the aforementioned medicines as the best-in-the-class. Also, these are the cheapest ED medicines available in the market which have FDA’s approval as well.