Discovery Of Sildenafil Citrate
Sildenafil citrate is a generic medical compound which was first formulated by an elite group of scientists in the year 1991. The rationale behind the discovery of sildenafil citrate was to treat Angina or chest pain. Soon, several trials were started and the novel compound was tested on different parameters in laboratories. Although, the newly synthesized drug—Sildenafil showed promises on the targeted disease (angina) in the initial trials gradually the efficacy of the drug was found inconsistent and the researchers deemed that experiment a failure.
A lot of time, money and researchers’ hard work were devoted for the discovery of sildenafil, probably these factors reasoned for the continuation of further modifications of formula and following trials on sildenafil. In 1996, sildenafil citrate was rediscovered as the anti-impotence medication—it was a revelation of that era in medical science since no other drug was ever formulated till then which could treat Erectile Dysfunction or impotence. This time, the efficacy of this drug on impotence was found to be consistent on erectile disability.
The company which funded the experiments on sildenafil—Pfizer soon managed to get the clearance from Food and Drug Association (FDA) and the manufacturing company started selling generic sildenafil tablets 100mg under the trade name—Viagra.
Working Mechanism Of Sildenafil Tablets
Viagra is classified as a PDE 5 inhibitor which contained vasodilator properties—a drug that dilates the blood vessels to improve the blood circulation in the body (especially penile region). The drug works in the system by enhancing the nitric oxide that relaxes the smooth muscles of the penis and allows the corpora cavernosum of the penis to be engorged with oxygenated blood. The sufficient supply of blood resuscitates the erectile tissues and allows the user of the drug to gain a healthy and long-lasting erection.
Viagra In UK Lost Popularity
Followed by the clearance by FDA, Viagra in UK and US became rapidly popular and the sales started to flurry within a short period of time. The commercial success of the branded sildenafil tablets lasted up to 2005. From 2005 onwards, several other pharmaceutical manufacturers introduced many other generic formulations which could surpass the efficacy of sildenafil tablets. Tadalafil is one of the best examples—patented by the pharmaceutical giant Eli Lilly, the pharmaceutical compound was proven to be effective for up to 36 hours on erections. Other generic medicinal compounds like Vardenafil & Avanafil were patented as PDE 5 inhibitors as well. A collective impact was evident on the sales figures of Viagra in UK and US.
People Started To Buy Sildenafil Tablets Under New Trade Name—Kamagra
The drug which totally superseded Viagra in 2009 was Kamagra. A pharmaceutical brand introduced by an Asian pharmaceutical giant, Ajanta Pharmaceuticals Pvt. Ltd. The patent laws of Pfizer manufactured Sildenafil doesn’t apply in the eastern geographies, this allowed Ajanta to come up with their own version of sildenafil tablets. A new brand of sildenafil citrate was introduced to the pharmaceutical market with the name of Kamagra. Subsequently, the new trade name of sildenafil citrate received the preliminary approval from European Union (EU) and got the legit certificates from (FDA), which are prerequisites for any medical compound to be traded commercially.
The prime reason for Kamagra’s edge over Viagra is its economical price. Whereas Kamagra costs only £0.69, Viagra comes at a whopping price of £8 per pill.
Irrespective of the trade name, the recommended dose of sildenafil tablets is 100mg for people who have been facing the problem of impotence for quite some time. For those who are at the onset of the erectile dysfunction can start off with a sildenafil citrate 50 mg dose. Scientific studies suggest that a dose of sildenafil tablets 100mg can stay effective on the erections for up to 8 hours. The best of the medical practitioners have become proponents of the drug and have been seen endorsing Kamagra on different platforms.